The Club World Cup final victory over Paris Saint-Germain last summer was probably Enzo Maresca’s finest hour as Chelsea manager. He devised a gameplan, pinging balls over Nuno Mendes for Cole Palmer to chase, backed up by Malo Gusto, that tore the European champions apart in the first half. Liam Rosenior may try to exploit the same vulnerability, but this is a Chelsea that look weary, their exertions in the US perhaps having left them fatigued.
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Massively parallel reporter assays across five cell types identify thousands of causal, noncoding regulatory variants among 220,000 loci, revealing diverse regulatory mechanisms shaping complex traits and disease.